Michelle A. Clark, Ph.D.
Cardiovascular research conducted by Dr. Michelle A. Clark and her research team at NSU's Barry and Judy Silverman College of Pharmacy is focused on delineating the molecular pathways that are involved in blood pressure control. This research encompasses pharmacology and neuroscience, specifically determining the role of the renin-angiotensin system (RAS) in the control of hypertension and other types of cardiovascular diseases. This interest is addressed by studying receptors for angiotensin peptides, the intracellular mechanisms that respond to receptor activation, and the cellular processes that are evoked by intracellular signaling molecules. Further, the interaction of the RAS with other systems is also explored.
Primary focus is on using transgenic rat models of hypertension to determine some of the responses that govern the development of hypertension in rat models. Research techniques involve using primary cultured brain cells (astrocytes and neurons) and vascular smooth muscle cells (VSMCs) to determine the responses of angiotensin peptides in rat models. The major focus is on the molecular pathways that can be dysregulated in hypertension, and to elucidate targets that can be perturbed to identify causes of the disease. An understanding of the processes that are different in these hypertensive models will provide insight into the pathology and treatment of hypertension as well as other pathologies.
From left to right: Shmuel Negussie, Waad Samman, Michelle Clark, Ann Tenneil O’Connor, Michael Dressler