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REALIZING POTENTIAL

Realizing Potential

Dr. Speth's Research Team: Cardiovascular Research

Research Interests: Brain angiotensin system and its physiological actions, brain angiotensin receptors and binding sites, angiotensin metabolizing enzymes, radioligand binding assays, receptor autoradiography, radioiodination of ligands for receptor and enzyme characterization.

Dr. Speth's Reserach Group

From left to right: Robert Speth, Ph.D., Jamala Swindle, Andrea Linares, Luz Gonzalez-Reiley, Kira Santos, Yaneve Shemesh.

  1. Characterization of neurolysin as the novel non-AT1 non-AT2 angiotensin binding site in the brain.
  2. Development of a novel radioligand for assay of angiotensin-converting enzyme-2 (ACE-2).
  3. Analysis of agonist and antagonist radioligand binding in a rat model of biased agonistic signaling.
  4. Immunohistochemical labeling of angiotensin receptor subtypes in the adrenal and brain.
  5. Analysis of relative abilities of angiotensins II and III to signal in the brain.
  6. Development of aminopeptidase resistant analogs of angiotensin II.
  • Michael Bader, Max Delbruck Center for Molecular Medicine, Berlin, Germany
  • Mark Brownfield, College of Veterinary Medicine, University of Wisconsin
  • Lisa Cassis, University of Kentucky
  • Emanuel Escher, Université de Sherbrooke
  • Yumei Feng, College of Medicine, Tulane Univ
  • Justin Grobe, College of Medicine University of Iowa
  • Joseph Harding, Dept. Vet. Comp. Anat. Pharmacol. Physiol. Washington State Univ.
  • Carrie Haskell-Luevano, College of Pharmacy, University of Minnesota
  • Vardan Karamyan, Texas Tech University Health Science Center
  • Sadashiva Karnik, Cleveland Clinic Foundation
  • Michael Katovich, College of Pharmacy, Univ Flroida
  • Eric Lazartigues, Louisiana State University Health Science Center
  • Christine Maric, University of Mississippi Medical Center
  • Theresa Milner, College of Medicine, Cornell University
  • Mariana Morris, College of Medicine, Wright State Univ.
  • Virginia Pickel, College of Medicine, Cornell University
  • Lakshmi Pulakat, College of Medicine, University of Missouri
  • Mohan Raizada, College of Medicine, Univ Florida
  • Nour-Eddine Rhaleb, Henry Ford Hospital, Detroit MI
  • Curt Sigmund, College of Medicine University of Iowa
  • Colin Sumners, College of Medicine, Univ Florida
  • Alan Sved, University of Pittsburgh
  • Juan Saavedra, Section on Pharmacology, National Institute of Mental Health
  • Kathryn Sandberg, College of Medicine, Georgetown Univ.
  • Robson Santos, Federal University of Minas Gerais
  • James Sowers, College of Medicine, University of Missouri
  • Thomas Walther, University of Hull
  • John Wright, Dept. Psychology, Washington State University
2/10-6/12 "Brain specific non-AT1, non-AT2 angiotensin binding site"(P.I. Robert Speth)
7/10-6-11 Diversity Supplement for Andrea Linares; NIH
7/10-6-11 Diversity Supplement for Luz Gonzalez; NIH
7/10-6-11 Diversity Supplement for Jamala Swindle; NIH
7/10-6-11 Diversity Supplement for Kira Santos; NIH
7/10-6/12 "Mechanisms of antihypertensive actions of angiotensin-converting enzyme-2 (ACE-2)"; Chancellor's Faculty Development Research Grant (Nova Southeastern University) (P.I. Robert Speth)
7/11-6/12 "Differential Desensitization of Salt Appetite and Thirst by Brain Angiotensin"; Chancellor's Faculty Development Research Grant (Nova Southeastern University) (P.I. Robert Speth)
1/12-12/16 Mechanisms of ACE2 dysregulation in neurogenic hypertension; NIH (P.I. Eric Lazartigues)
7/12-6/13 "Development of a radioligand for assay of angiotensin-converting enzyme-2(ACE-2)"; NIH 1R15HL113905-01 Impact score 21 (P.I. Robert Speth)
12/12-11/17 "Metalloendopeptidase neurolysin and the brain renin-angiotensin system"; NIH (P.I. Vardan Karamyan, Subcontractor Robert Speth)
12/12-11/15 "Regulation of human angiotensinogen gene after ethanol"; NIH (P.I. Rais Ansari)
7/12-6/13 "Development of radioligands for ACE-2 and the (pro)renin receptor (P)RR"; President's Faculty Development Research Grant (Nova Southeastern University)

US Provisional patent Application No. 61/567,290 "Radioiodinatable Angiotensin-Converting Enzyme-2 (ACE-2) Modulating Compounds, Preparation Thereof, and Methods for Use Thereof" Filed December 6, 2011 (NSU11-08).

  • Wangler NJ, Santos K, Schadock I, Hagen FK, Escher E, Bader M, Speth RC, Karamyan VT 2012 "Identification of membrane-bound variant of endopeptidase 24.16 as the non-AT1, non-AT2 angiotensin binding site" J. Biol Chem. 287: 114-122.
  • Bourassa EA, Fang X, Sved AF, Speth RC 2010 AT1 angiotensin II receptor and novel non-AT1, non-AT2 angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat. Brain Res. 1359: 98-106
  • Speth RC 2010 Animal research in the development of kidney transplantation ... A professional perspective. Invited review. Kidney News 2: 8-9.
  • Karamyan VT, Arsenault J, Escher E, Speth RC. (2010) Preliminary biochemical characterization of a novel non-AT1, non-AT2 angiotensin binding site in rat brain. Endocrine 37: 442-448
  • Rabey FM, Karamyan VT, Speth RC. (2010) Distribution of a novel binding site for angiotensins II and III in mouse tissues. Regul Pept. 162: 5-11.
  • Bourassa EA, Speth RC. (2010) Water Deprivation Increases Angiotensin-Converting Enzyme but not AT1 Receptor Expression in Brainstem and Hypothalamic Nuclei of the rat. Brain Res., 1319:83-91
  • Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. (2010) Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ. Res. 106: 373-82.
  • Müller D, Greenland K, Speth RC, Middendorff R. (2010) Neuronal differentiation of NG108-15 cells has impact on nitric oxide- and membrane (natriuretic peptide receptor A) cyclic GMP-generating proteins. Molecular and Cellular Endocrinology 320: 118-27.

Contact: Dr. Robert Speth

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