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Dr. Jean Latimer's Research Team: Breast Cancer and Leukemia

Research Interests: DNA repair, stem cells, breast tissue engineering, breast cancer etiology, leukemia recurrence, genomic instability, mutation, precocial breast development, environmental causes of cancer, chemotherapy drugs that impact Nucleotide Excision Repair, somatic mutation in autism.

Dr. Latimer's research team includes Dr. Stephen Grant an expert in somatic mutation that occurs with aging, with cancer development and as a result of exposure to chemotherapy and certain environmental agents. Collaborations include proteomics and microarray specialists at the University of Pittsburgh and Duquesne University as well as members of Nova Southeastern Schools of Osteopathic Medicine and Dentistry.

Dr. Latimer's Lab

Recent Papers

  1. Kelly, C.M., and Latimer, J.J. (2005) Unscheduled DNA synthesis: a functional assay for global genomic nucleotide excision repair. Methods in Molecular Biology 291: 303—320.
  2. Johnson, J.M., and Latimer, J.J. (2005) Analysis of DNA repair using transfection-based host cell reactivation. Methods in Molecular Biology 291: 321—335.
  3. Latimer, J.J., Rubinstein, W.S., Johnson, J.M., Kanbour-Shakir, A., Vogel, V.G., and Grant, S.G. (2005) Haploinsufficiency for BRCA1 is associated with normal levels of DNA nucleotide excision repair in breast tissue and blood lymphocytes. BMC Medical Genetics 6: 26 (published online 06-14-05).
  4. Rubinstein, W.S., Latimer, J.J., Sumkin, J.H., Huerbin, M.B., Grant, S.G., and Vogel, V.G. (2006) Prospective screening study of 0.5 Tesla dedicated magnetic resonance imaging for the detection of breast cancer in young, high risk women. BMC Women's Health 6: 10 (published online 6-26-06).
  5. Donovan, M., Miles, T.D., Latimer, J.J., Grant, S., Talbott, E., Sasco, A.J., and Davis, D.L. (2006) Association between biomarkers of environmental exposure and increased risk of breast cancer. Nature Reviews Cancer 6: c1 (reply: Nature Reviews Cancer 6: c2).
  6. Grant, S.G., Das, R., Cerceo, C.M., Rubinstein, W.S., and Latimer, J.J. (2007) Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier. Pathology and Oncology Research 13: 276—283 (published online 12-25-07).
  7. Latimer, J.J., Johnson, J.M., Miles, T.D., Dimsdale, J.M., Edwards, R.P., Kelley, J.L., and Grant, S.G. (2008) Cell-type-specific level of DNA nucleotide excision repair in primary human mammary and ovarian epithelial cell cultures. Cell and Tissue Research 333: 461—467 (published online 6-25-08).
  8. Sajithlal, G.S., Rothermund, K., Zhang, F., Dabbs, D.J., Latimer, J.J., Grant, S.G., and Prochownik, E.V. (2010) Permanently blocked stem cells derived from breast cancer cell lines. Stem Cells 28: 1008—1018 (published online 4-7-10).
  9. Latimer, J.J., Johnson, J.M., Kelly, C.M., Miles, T.D., Beaudry-Rodgers, K.A., Lalanne, N.A., Vogel, V.G., Kanbour-Shakir, A., Kelley, J.L., Johnson, R.J., and Grant, S.G. (2010) Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer. Proceedings of the National Academy of Sciences (U.S.A.) 50: 21725—21730 (published online 11-30-10).
  10. Visus, C., Ito, D., Dhir, R., Szczepanski M.J., Chang, Y. J., Latimer, J.J., Grant, S.G., and DeLeo, A.B. (2011) Identification of hydroxsteroid (17b) dehydrogenase type 12 (HSD17B12) as a CD8+ T-cell-defined human tumor antigen of human carcinomas. Cancer Immunology Immunotherapy 60: 919—929 (published online 3-16-11).

Contact: Dr. Jean J. Latimer

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