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BRAIN Team

Publications

  1. Karhu E, Zukerman R, Eshraghi R, Mittal J, Deth R, Trivedi M, Castejon Ana, Mittal R, Eshraghi A. Nutritional Interventions for Autism Spectrum Disorder. Nutr Rev. 2019 Dec 26. pii: nuz09
  2. Hodgson NW, Waly MI, Trivedi MS, Power-Charnitsky V-A, Deth RC. Methylation-related metabolic effects of D4 dopamine receptor expression and activation. Transl Psychiatry. 2019 Nov 12;9(1):295.
  3. Ye Q, Trivedi M, Zhang Y, Böhlke M, Alsulimani H, Chang J, Maher T, Deth R, Kim J. Brain iron loading impairs DNA methylation and alters GABAergic function in mice. FASEB J. 2019 Feb;33(2):2460-2471.
  4. Padmanabhan S, Waly MI, Taranikanti V, Guizani1 N, Ali A, Rahman MS, Al-Attabi1 Z, Al-Malki1 RN, Al-Maskari SNM, Al-Ruqaishi BRS, Dong J, Deth RC. Folate/Vitamin B12 Supplementation Combats Oxidative Stress-associated Carcinogenesis in a Rat Model of Colon Cancer. Nutr Cancer. 2018 Oct 29:1-11.
  5. Eshraghi RS, Deth RC, Mittal R, Aranke M, Kay SS, Moshiree B, Eshraghi AA. Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism. Front Cell Neurosci. 2018 Aug 15;12:256. doi:10.3389/fncel.2018.00256. eCollection 2018.
  6. Terhune TD, Deth RC. Aluminum Adjuvant-Containing Vaccines in the Context of the Hygiene Hypothesis: A Risk Factor for Eosinophilia and Allergy in a Genetically Susceptible Subpopulation? Int J Environ Res Public Health. 2018 May 3;15(5). pii: E901. doi:10.3390/ijerph15050901.
  7. Kern JK, Geier DA, Deth RC, Sykes LK, Hooker BS, Love JM, Bjørklund G, Chaigneau CG, Haley BE, Geier MR. Systematic Assessment of Research on Autism Spectrum Disorder (ASD) and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research. Sci Eng Ethics. 2017 Dec;23(6):1691-1718. doi: 10.1007/s11948- 017-9983-2.
  8. Schrier MS, Trivedi MS, Deth RC. Redox-Related Epigenetic Mechanisms in Glioblastoma: Nuclear Factor (Erythroid-Derived 2)-Like 2, Cobalamin, and Dopamine Receptor Subtype 4. Front Oncol. 2017 Mar 30;7:46.
  9. Deth R, Clarke A, Ni J, Trivedi M. Clinical evaluation of glutathione concentrations after consumption of milk containing different subtypes of β-casein: results from a randomized, cross-over clinical trial. Nutr J. 2016 Sep 29;15(1):82.
  10. Zang T, Pottenplackel LP, Handy DE, Loscalzo J, Dai S, Deth RC, Zhou ZS and Ma J. Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated HomocysteineUsing a Specific Chemical Labeling Method. Molecules 2016, 21, 1195;   doi:10.3390/molecules21091195.
  11. Trivedi MS, Hodgson NW, Walker SJ, Trooskens G, Nair V, Deth RC. Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells. Nutr Metab (Lond). 2015 Dec 9;12:54. doi: 10.1186/s12986-015-0050-1. eCollection 2015. PMID: 26664459.
  12. Waly M, Power-Charnitsky V-A, Hodgson N, Sharma A, Audhya T, Zhang Y and Deth R. Alternatively Spliced Methionine Synthase in SH-SY5YNeuroblastoma Cells: Cobalamin and GSH Dependence and Inhibitory Effects of NeurotoxicMetals and Thimerosal. Oxidative Medicine and Cellular Longevity 2016:6143753. doi: 10.1155/2016/6143753.
  13. Zhang Y, Hodgson NW, Trivedi MS, Abdolmaleky HM, Fourniere M, Cuenod M, Quang Do K, Deth RC. Decreased brain levels of vitamin B12 in aging, autism and schizophrenia. PLOS ONE 2016 Jan 22;11(1):e0146797. doi: 10.1371/journal.pone.0146797. eCollection PMID: 26799654.
  14. Zhang Y, Hodgson N, Trivedi M and Deth RC. Neuregulin-1 promotes glutathione-dependent neuronal cobalamin metabolism by stimulating cysteine uptake. Oxidative Medicine and Cellular Longevity. 2016;2016:3849087.
  15. Trivedi M, Zhang Y, Lopez-Toledano M, Clarke A, Deth R. Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: implications for redox-based epigenetic changes. J Nutr Biochem. 2016 Nov;37:39-46.
  16. Trivedi MS, Deth RC. Redox-based Epigenetic status in Drug Addiction: Potential mediator of drug-induced gene priming phenomenon and use of metabolic intervention for symptomatic treatment in drug addiction. Frontiers in Neuroscience 2015; 8:444.
  17. Terhune TD, Deth RC. A role for impaired regulatory T cell function in adverse responses to aluminum adjuvant-containing vaccines in genetically susceptible individuals. Vaccine. 2014, 32(40):5149-55.
  18. Walach, H, Mutter, J and Deth, RC. Inorganic Mercury and Alzheimer’s Disease-Results of a Review and a Molecular Mechanism. pp 593-602 in Diet and Nutrition in Dementia and Cognitive Decline ed. C. R. Martin and V.R. Preedy, 2015, Elsevier, (London, UK).
  19. Trivedi, MS, Shah, JS, Al-Mughairy, S, Hodgson NW, Simms B, Trooskens BA, Van Criekinge W, Deth RC. Food-derived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences. J Nutritional Biochemistry 2014 ;25(10):1011-8.
  20. Trivedi M, Shah J, Hodgson N, Byun HM, Deth R. Morphine induces redox-based changes in global DNA methylation and retrotransposon transcription by inhibition of excitatory amino Acid transporter type 3-mediated cysteine uptake. Mol Pharmacol. 2014; 85(5):747-57.
  21. Hodgson, N.W, Waly, M.I., Al-Farsi, Y.M., Al-Sharbati, M.M., Al-Farsi, O., Ali, A., Ouhtit, A., Zang, T., Zhou,, Z.S., Deth, R.C. Decreased glutathione and elevated hair mercury levels are associated with nutritional deficiency-based autism in Oman. Exp. Biol. Med. (Maywood). 2013, 239(6):697-706.
  22. Deth R, Trivedi MS, Hodgson NW, Muratore CR and Waly MI. Redox-Methylation Theory and Autism. In: Comprehensive Guide to Autism, Springer, 2013.
  23. Deth RC. Autism: a redox/methylation disorder. Glob Adv Health Med. 2013; 2(6):68-73.
  24. Yeter D, Deth R, Kuo H-C. Mercury Promotes Catecholamines Which Potentiate Mercurial Autoimmunity and Vasodilation: Implications for Inositol 1,4,5-Triphosphate 3-Kinase C Susceptibility in Kawasaki Syndrome. Korean Circ J. 2013; 43:581-591.
  25. Kocsis B, Lee P, Deth R. Enhancement of gamma activity after selective activation of dopamine D4 receptors in freely moving rats and in a neurodevelopmental model of schizophrenia. Brain Struct Funct. 2014 Nov; 219(6):2173-80. doi: 10.1007/s00429-013-0607-6.
  26. Hodgson N, Trivedi M, Muratore C, Li S, Deth R. Soluble Oligomers of Amyloid-β Cause Changes in Redox State, DNA Methylation, and Gene Transcription by Inhibiting EAAT3 Mediated Cysteine Uptake. J Alzheimers Dis. 2013; 36(1):197-209.
  27. Muratore CR, Hodgson NW, Trivedi MS, Abdolmaleky HM, Persico AM, Lintas C, De la Monte S, Deth RC. Age-dependent decrease and alternative splicing of methionine synthase mRNA in human cerebral cortex and an accelerated decrease in autism. PLoS One. 2013;8(2):e56927.
  28. Al-Farsi YM, Waly MI, Deth RC, Al-Sharbati MM, Al-Shafaee M, Al-Farsi O, Al-Khaduri MM, Al-Adawi S, Hodgson NW, Gupta I, Ouhtit A. Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. Nutrition. 2013 (13) 00196-2.
  29. Al-Farsi YM, Waly MI, Al-Sharbati MM, Al-Shafaee MA, Al-Farsi OA, Al-Khaduri MM, Gupta I, Ouhtit A, Al-Adawi S, Al-Said MF, Deth RC. Levels of Heavy Metals and Essential Minerals in Hair Samples of Children with Autism in Oman: a Case-Control Study. Biol Trace Elem Res. 2013 Feb;151(2):181-6.
  30. Raymond, L.J., Deth, R.C., Ralston, N.V.C. Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and Pathology. Autism Res Treat. 2014:164938.
  31. Kern, J.K., Geier, D.A., Geier, M.R., Deth, R.C. Are ASD and ADHD a Continuum? A Comparison of Pathophysiological Similarities Between the Disorders. Journal of Attention Disorders 2015 Sep;19(9):805-27. doi: 10.1177/1087054712459886.
  32. Trivedi, M.S., Deth, R.C. Role of a Redox-Based Methylation Switch in mRNA Life Cycle (Pre-and Post-Transcriptional Maturation) and Protein Turnover: Implications in Neurological Disorders. Frontiers in Neuroscience. 2012;6:92.
  33.   Deth, R.C. Genomics, intellectual disability, and autism. (Letter to the Editor) N Engl J Med. 2012; 366:2231-2.
  34. Al-Farsi, Y.M., Al-Sharbati, M.M., Waly, M.I., Al-Farsi, O.A., Al-Shafaee, M.A., Al-Khaduri, M.M., Trivedi, M.S., Deth, R.C.. Effect of suboptimal breast-feeding on occurrence of autism: A case-control study. Nutrition. 2012 Jul;28(7-8):e27-32.
  35. Waly, M.I., Hornig, M., Trivedi, M., Hodgson, N., Kini, R., Ohta, A., Deth, R. Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism. Autism Research and Treatment. 2012 doi:10.1155/2012/190930.
  36. Dufault, R., Lukiw, W.J., Crider, R., Schnoll, R., Wallinga, D., Deth, R. A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States. Clinical Epigenetics. 2012 Apr 10;4(1):6.
  37. Terhune, T.D., Deth, R.C. How Aluminum Adjuvants Could Promote and Enhance Non-target IgE Synthesis in a Genetically-vulnerable Sub-population. J Immunotoxicology. 2013 Apr-Jun;10(2):210-22.
  38. Yeter, D., Deth, R. ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3. Autoimmunity Reviews. 2012 Oct;11(12):903-8. doi:10.1016/j.autrev.2012.03.006.
  39. Ali, A., Waly, M.I., Al-Farsi, Y.M., Essa, M.M, Al-Sharbati, M.M., and Deth, R.C. Hyperhomocysteinemia among Omani autistic children:a case-control study. Acta Biochimica Polonica 58: 547-51, 2011.
  40. Deth, R.C., Hodgson, N.W., Trivedi, M.S., Muratore, C.R., and Waly, M.I. Autism: a neuroepigenetic disorder. Autism Science Digest 3: 7-18 (2012).
  41. Al-Farsi, Y.M., Al-Sharbati, M.M., Waly, M.I., Al-Farsi, O.A, Al-Shafaee, M.A. and Deth, R.C. Malnutrition among preschool-aged autistic children in Oman. Research in Autism Spectrum Disorders. 5 1549-52 (2011).
  42. Deth, R.C. The Redox/Methylation Hypothesis of Autism. U.S. Psychiatry 3: 48-52 (2010).
  43. Waly, M.I., Kharbanda, K.K. and Deth, R.C. Ethanol Lowers Glutathione in Rat Liver and Brain and Inhibits Methionine Synthase in a Cobalamin-dependent Manner. Alcoholism: Clinical and Experimental Research 35: 277-83 (2011).
  44. Deth, R.C., Waly, M., Muratore, C. and Hodgson, N. Redox Imbalance and the Metabolic Pathology of Autism. In Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms Section V: Autism Spectrum Disorders Section Ed. Isaac Pessah, John Wiley and Sons, Hoboken, (2010).
  45. Mutter, J., Curth, A., Naumann, J., Deth, R. and Walach, H. Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism. J Alzheimer’s Disease 22: 357-374 (2010).
  46. Deth, R.C. The Redox/Methylation Hypothesis of Autism: A Molecular Mechanism for Heavy Metal-induced Neurotoxicity. In Autism: Oxidative Stress, Inflammation and   ImmuneAbnormalities, A. Chauhan, V. Chauhan, W.T. Brown Eds., Taylor & Francis/CRC Press, Boca Raton (2009).
  47. Kane, P., Cartaxo, A., and Deth, R.C. Nutritional issues in the causation and treatment of autism. In Food and Nutrients in Disease Management, Ingrid Kohlstadt Ed., CRC Press, Boca Raton (2008).
  48. Deth, R.C., Muratore, C., and Waly, M. Oxidative stress in autism and its implications for dopamine-stimulated phospholipid methylation in Neurochemical Basis of Autism: Molecules to Minicolumns, Gene Blatt Ed., Springer, New York (2009).
  49. Deth, R., Muratore, C., Benzecry, J., Power-Charnitsky, V., and Waly, M. How environmental and genetic factors combine to cause autism: A Redox/Methylation Hypothesis. Neurotoxicology 29: 190-201 (2007).
  50. Kuznetsova, A.Y., and Deth, R.C. A model for gamma oscillations induced by D4 dopamine receptor-mediated phospholipid methylation. J. Computational Neuroscience 24 (3):314-29 (2008).
  51. Culley, D.J., Raghavan, S.V., Waly, M., Baxter, M.G., Yukhananov, R., Deth, R.C. and Crosby, G. Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats. Anesthesia and Analgesia 105: 83-88 (2007).
  52. Deth, R.C., Kuznetsova, A. and Waly, M. Attention-related signaling activities of the D4 dopamine receptor in Cognitive Neuroscience of Attention, Michael Posner Ed., Guilford Publications Inc., New York (2004). pp 269-282.
  53. Waly, M., Banerjee, R., Choi, S.W., Mason, J., Benzecry, J., Power-Charnitsky, V.A, Deth, R.C. PI3-kinase regulates methionine synthase: Activation by IGF-1 or dopamine and inhibition by heavy metals and thimerosal. Molecular Psychiatry 9: 358-370 (2004).
  54. Deth, R.C., Sharma, A. and Waly, M. Dopamine-stimulated solid-state signaling: A novel role for single-carbon folates in human attention. Proc. 12th Int. Symp. Chem. Pteridines and Folates.  Kluwer Academic Press (2002).
  55. Sharma, A. and Deth, R.C. Protein kinase C regulates basal and D4 dopamine receptor-mediated phospholipid methylation in neuroblastoma cells. Eur. J. Pharmacol. 427: 83-90 (2001).
  56. Zhao, R., Chen, Y., Tan, W., Waly, M., Malewicz, B., Stover, P., Rosowsky, A. and Deth, R.C. Influence of single-carbon folate and de novo purine synthesis pathways on D4 dopamine receptor-mediated phospholipid methylation. J. Neurochem. 78: 788-796 (2001).
  57. Sharma, A., Kramer, M., Wick, P.F., Liu, D., Chari, S., Shim, S., Tan, W.-B., Ouellette, D., Nagata, M., DuRand, C., Kotb, M. and Deth, R.C. Dopamine D4 receptor-mediated methylation of membrane phospholipids and its implications for mental illnesses such as schizophrenia. Molecular Psychiatry 4: 235-246 (1999).
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